Our ability to rapidly and cheaply sequence a genome, ranging from humans, to native and domesticated plants and animals, and infectious bacteria and viruses, has revolutionised the field of genetics. More than ever, we understand our genetic relationship to life on earth, uncovering surprising similarities between our genome and the genomes of small worms and fruit flies. This subject will compare the genomes of different organisms and apply the methodology and theory of modern genetics to understand how the diversity of genetic variability impacts the structure and evolution of genomes, the expression of genes, and ultimately on the health and form of an organism.